# White Blood Cell and Peripheral Blast Countsin Leukemia Patients with Non-Graying WBC-Diff Scattergram
> Lismayanti L.

URL kanonis: https://discover.unhas.ac.id/publications/white-blood-cell-and-peripheral-blast-countsin-leukemia-patients-with-non-grayin
Jurnal / Konferensi: Indonesian Journal of Clinical Pathology and Medical Laboratory
Tahun terbit: 2024
DOI: https://doi.org/10.24293/ijcpml.v31i1.2222
ISSN: 24774685
Kuartil SJR: Q4
Citations: 0

## Authors
- Lismayanti L.

## Abstract
Graying scattergram of White Blood Cell differential (WBC-diff) is often accompanied by blasts in the blood and/or leukocytosis in leukemia patients. Therefore, monitoring White Blood Cell (WBC) and peripheral blast count is crucial for patient management. In contrast, patients with non-graying WBC-diff scattergrams may have varying WBC counts and peripheral blasts. This study aimed to establish the cut-off values of WBC and peripheral blast counts that could predict a non-graying scattergram in leukemia patients. A retrospective descriptive study with a cross-sectional design analyzed secondary data from 21 leukemia patients. The acute and chronic leukemia diagnosis were based on bone marrow aspirates, which simultaneously showed a graying WBC-diff scattergram on Complete Blood Count (CBC). Receiver Operating Characteristic (ROC) curve analysis was conducted when the patient’s CBC displayed a non-graying scattergram. The cut-off value for WBC count was 16,380 x 109/L with an Area Under Curve (AUC) of 0.932, a sensitivity of 85.7%, p = 0.001, and the cut-off for peripheral blast count was 35.5% with an AUC of 0.872, the sensitivity of 76.2%, p=0.001. The results suggest that a non-graying scattergram of the WDF channel in leukemia is more likely associated with WBC counts below 16,380 x 109/L and peripheral blast counts below 35.5%, which have excellent and good predictive value.

## Keywords
- Medicine
- White blood cell
- Peripheral blood
- White (mutation)
- Leukemia
- Peripheral
- Internal medicine
- Pathology
- Immunology
- Gene
- Chemistry
- Biochemistry

---
Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
Saat mengutip, gunakan DOI bila tersedia atau URL kanonis di atas.