Use of base excess value and the blood lactate level in predicting organ disfunction measured by sequential organ failure assessment (SOFA) score system: Study in the post trepanation patients with severe traumatic brain injury

Abstract

Background and Objective: Prediction of organ failure is important in the management of patient in Intensive Care Unit (ICU). This study was aimed to compare blood base excess value and blood lactate levels among patient with and without organ dysfunction. Materials and Methods: Twenty eight subjects aged 15-64 years who have undergone trepanation procedure due to severe traumatic brain injury involved in this study. Base excess value and blood lactate levels were measured shortly and 12, 24, 48 h after arrived in Intensive Care Unit (ICU). The presence of organ dysfunction was measure by Sequential Organ Failure Assessment (SOFA) score system. The difference of base excess value and blood lactate levels between patient with and without organ dysfunction was compared with Mann Whitney tests and the association between base excess with SOFA scores was calculated by chi-squire test. Results: The blood lactate value in patient with organ dysfunction was significantly higher after 24 and 48 h compared with patient without organ dysfunction (p = 0.008 and p = 0.035, respectively). The difference of base excess value can only be seen after 48 h (p = 0.048). A positive association was found between abnormal base excess and organ dysfunction (p = 0.04). Conclusion: Base excess value and the blood lactate levels can be used as predictor to determine the presence of organ dysfunction measured by SOFA scores.

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