# Tumor-Penetrable Nitric Oxide-Releasing Nanoparticles Potentiate Local Antimelanoma Therapy
> Lee J.

URL kanonis: https://discover.unhas.ac.id/publications/tumor-penetrable-nitric-oxide-releasing-nanoparticles-potentiate-local-antimelan
Jurnal / Konferensi: ACS Applied Materials and Interfaces
Tahun terbit: 2021
DOI: https://doi.org/10.1021/acsami.1c07407
ISSN: 19448244
Kuartil SJR: Q1
Citations: 20

## Authors
- Lee J.

## Abstract
Although nitric oxide (NO) has been emerging as a novel local anticancer agent because of its potent cytotoxic effects and lack of off-target side effects, its clinical applications remain a challenge because of the short effective diffusion distance of NO that limits its anticancer activity. In this study, we synthesized albumin-coated poly(lactic-<i>co</i>-glycolic acid) (PLGA)-conjugated linear polyethylenimine diazeniumdiolate (LP/NO) nanoparticles (Alb-PLP/NO NPs) that possess tumor-penetrating and NO-releasing properties for an effective local treatment of melanoma. Sufficient NO-loading and prolonged NO-releasing characteristics of Alb-PLP/NO NPs were acquired through PLGA-conjugated LP/NO copolymer (PLP/NO) synthesis, followed by nanoparticle fabrication. In addition, tumor penetration ability was rendered by the electrostatic adsorption of the albumin on the surface of the nanoparticles. The Alb-PLP/NO NPs showed enhanced intracellular NO delivery efficiency and cytotoxicity to B16F10 murine melanoma cells. In B16F10-tumor-bearing mice, the Alb-PLP/NO NPs showed improved extracellular matrix penetration and spatial distribution in the tumor tissue after intratumoral injection, resulting in enhanced antitumor activity. Taken together, the results suggest that Alb-PLP/NO NPs represent a promising new modality for the local treatment of melanoma.

## Keywords
- Materials science
- Cytotoxicity
- Polyethylenimine
- Nitric oxide
- Conjugated system
- Biophysics
- Nanoparticle
- Bovine serum albumin
- PLGA
- Melanoma
- Nanotechnology
- Chemistry
- Cancer research
- Biochemistry
- Medicine
- Organic chemistry
- Transfection
- Polymer
- Biology
- In vitro
- Composite material
- Gene

---
Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
Saat mengutip, gunakan DOI bila tersedia atau URL kanonis di atas.