# Tracheospasmolytic activity of viteosin-A and vitexicarpin isolated from Vitex trifolia
> Alam G.

URL kanonis: https://discover.unhas.ac.id/publications/tracheospasmolytic-activity-of-viteosin-a-and-vitexicarpin-isolated-from-vitex-t
Jurnal / Konferensi: Planta Medica
Tahun terbit: 2002
DOI: https://doi.org/10.1055/s-2002-35650
ISSN: 00320943
Kuartil SJR: Q2
Citations: 52

## Authors
- Alam G.

## Abstract
The n-hexane extract that has shown activity in the tracheospasmolytic bioassay was fractionated by solvent extraction and from the major active fraction two compounds were isolated and identified as viteosin-A and vitexicarpin. These compounds blocked spontaneous contraction of isolated male guinea pig trachea induced by histamine; however only vitexicarpin was active in a model using sensitized guinea pig trachea stimulated by ovalbumin up to minimum dose of 1.3 x 10(-5) M. The result suggests that vitexicarpin is able to block effects of histamine released from sensitized mast cells possibly by stabilizing the mast cells membrane function.

## Keywords
- Histamine
- Ovalbumin
- Guinea pig
- Bioassay
- Vitex
- Chemistry
- Traditional medicine
- Contraction (grammar)
- Pharmacology
- Biology
- Medicine
- Immunology
- Endocrinology
- Antigen
- Genetics

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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