# Topical Effectiveness of Bitter Melon (Momordica charantia L.) Leaf Extract on Healing of Cut Wounds in Female Wistar Rats
> Nurti

URL kanonis: https://discover.unhas.ac.id/publications/topical-effectiveness-of-bitter-melon-momordica-charantia-l-leaf-extract-on-heal
Jurnal / Konferensi: Tropical Journal of Natural Product Research
Tahun terbit: 2025
DOI: https://doi.org/10.26538/tjnpr/v9i12.14
ISSN: 26160684
Kuartil SJR: Q3
Citations: 0

## Authors
- Nurti

## Abstract
Momordica charantia L. (bitter melon leaves) has long been utilized in traditional medicine for its anti-inflammatory and antioxidant properties. This research investigates the wound-healing efficacy of ointments formulated with bitter melon leaf extract. The extract was incorporated into ointments at concentrations of 5%, 10%, and 15%, and the formulations were compared with a negative control (base ointment) and a positive control consisting of Betadine® ointment (povidone–iodine 10% w/w). All preparations were applied topically once daily at approximately 0.1 g per wound. Wound recovery was assessed macroscopically using the Redness, Edema, Ecchymosis, Discharge, and Approximation (REEDA) scale, along with histopathological examinations conducted on day 15. Findings indicated that the 10% extract formulation provided the most effective acceleration of wound closure, with a median healing time of 8 days and superior histopathological outcomes in terms of re-epithelialization, fibroblast proliferation, and tissue remodeling. Statistical analyses using the Kruskal–Wallis and Mann–Whitney tests confirmed significant differences among groups (p < 0.05), revealing a non-linear dose–response pattern. The 15% formulation demonstrated reduced effectiveness, potentially related to increased viscosity or concentration-related cytotoxic effects. Overall, the study supports the potential of Momordica charantia L. extract, at an optimal concentration, as a promising plant-derived topical agent for wound healing.

## Keywords
- Momordica
- Traditional medicine
- Medicine
- Melon
- Wound healing
- Positive control
- Rat model
- Antioxidant
- Negative control
- Fibroblast
- Herbal extracts
- Pharmacology
- Statistical analysis
- Phytotherapy

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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