# Toll Like Receptor 4 Expression Profile in Mice Infected Mycobacterium Tuberculosis Given with Miana Leaves Extract (Coleus scutellarioides (L.) Benth) (Tuberculosis Preventive and Curative Mechanisms)
> Pakadang S.R.

URL kanonis: https://discover.unhas.ac.id/publications/toll-like-receptor-4-expression-profile-in-mice-infected-mycobacterium-tuberculo
Jurnal / Konferensi: Pharmacognosy Journal
Tahun terbit: 2022
DOI: https://doi.org/10.5530/pj.2022.14.63
ISSN: 09753575
Kuartil SJR: Q3
Citations: 4

## Authors
- Pakadang S.R.

## Abstract
Tuberculosis is an infectious disease of the respiratory tract caused by Mycobacterium tuberculosis. During Mycobacterium tuberculosis infection, pathogens modulate TLR-4 receptor flow signaling, suggesting possible involvement of TLR-4 in the regulation of the host immune response. This study aims to determine the effect of miana leaf extract on the expression of toll like receptor 4 (TLR-4) in tuberculosis mice at the preventive and curative stages. Methods: Mice were divided into 3 groups with 7x replication. Providing 14 days of preventive treatment, 14 days of incubation and 14 days of curative treatment. Group 1 and group 3 were given Miana Leaves Extract (EDM) and placebo at all three stages. Group 2 was given EDM at the preventive and incubation stages, then they were given anti-tuberculosis drugs (OAT). Results: The results proved that EDM given as a preventive did not increase the expression of TLR-4 protein in healthy mice; Changes in expression of TLR-4 protein in M.tb-infected mice before and after curative EDM increased by 17%, after administration of placebo increased 97% and decreased 12% after OAT curative administration; Changes in expression of TLR-4 protein in M.tb-infected mice before preventive administration and after EDM curative administration increased by 20%, after administration of placebo increased 102% and decreased by 10% after the curative administration of OAT. Conclusions: EDM has potential as antituberculosis with TLR-4 regulatory mechanism.

## Keywords
- Tuberculosis
- Mycobacterium tuberculosis
- Medicine
- Immune system
- Receptor
- Pharmacology
- Placebo
- Toll-like receptor
- Immunology
- Internal medicine
- Innate immune system
- Pathology
- Alternative medicine

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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