Thrombosis marker levels at various levels of chronic obstructive pulmonary disease: degree of obstruction and severity

Abstract

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is characterized by persistent respiratory symptoms and airflow limitation caused by airway and alveolar abnormalities. This disease mainly occurs in patients who smoke and are over 40 years old. Increased risk of cardiovascular disease and increased inflammatory markers in COPD sufferers are the causes of increased coagulation processes. Several biomarkers that can be examined and used as parameters for the occurrence of thrombosis in COPD patients in this study are platelets, prothrombin time (PT), international normalized ratio (PT), activated partial thromboplastin time (aPTT), D-dimer, and fibrinogen.METHODS: A cross-sectional study among COPD patients at Wahidin Sudirohusodo Hospital and its network from March to April 2023. Each patient took venous blood samples and then examined levels of platelets, PT, INR, aPTT, D-dimer, and fibrinogen in the Clinical Pathology Laboratory of Wahidin Sudirohusodo Hospital. Baseline data were descriptively summarized. All statistical analyses were performed using the Statistical Program for Social Sciences (SPSS 24; IBM Corp., Armonk, NY, USA).RESULTS: This study involved 40 patients. The results showed relationship between the fibrinogen and the degree of obstruction (P=0.00). The FEV1 correlation with fibrinogen was significant with very strong correlation ρ=-0.824. There was no relationship between severity and thrombosis markers in this study except fibrinogen.CONCLUSIONS: There is relationship between fibrinogen and COPD degree of obstruction. There was no relationship between plasma levels of platelets, PT, INR, aPTT, D-dimer, and fibrinogen with the severity of COPD in this study.

Access to Document

Other files and links

• Link to publication in Scopus
• Open Access Version Available

Fingerprint