# The role of IL-6-174 G/C polymorphism and intraocular IL-6 levels in the pathogenesis of ocular diseases: a systematic review and meta-analysis
> Ulhaq Z.S.

URL kanonis: https://discover.unhas.ac.id/publications/the-role-of-il-6-174-gc-polymorphism-and-intraocular-il-6-levels-in-the-pathogen
Jurnal / Konferensi: Scientific Reports
Tahun terbit: 2020
DOI: https://doi.org/10.1038/s41598-020-74203-9
ISSN: 20452322
Kuartil SJR: Q1
Citations: 36

## Authors
- Ulhaq Z.S.

## Abstract
Interleukin-6 (IL-6) is one of the key regulators behind the inflammatory and pathological process associated with ophthalmic diseases. The role of IL-6-174 G/C polymorphism as well as intraocular IL-6 levels among various eye disease patients differ across studies and has not been systematically reviewed. Thus, this study aims to provide a summary to understand the relationship between IL-6 and ophthalmic disease. In total, 8,252 and 11,014 subjects for IL-6-174 G/C and intraocular levels of IL-6, respectively, were retrieved from PubMed, Scopus and Web of Science. No association was found between IL-6-174 G/C polymorphisms with ocular diseases. Subgroup analyses revealed a suggestive association between the GC genotype of IL-6-174 G/C with proliferative diabetic retinopathy (PDR). Further, the level of intraocular IL-6 among ocular disease patients in general was found to be higher than the control group [standardized mean difference (SMD) = 1.41, 95% confidence interval (CI) 1.24-1.58, P < 0.00001]. Closer examination through subgroup analyses yielded similar results in several ocular diseases. This study thus indicates that the IL-6-174 G/C polymorphism does not predispose patients to ocular disease, although the GC genotype is likely to be a genetic biomarker for PDR. Moreover, intraocular IL-6 concentrations are related to the specific manifestations of the ophthalmic diseases. Further studies with larger sample sizes are warranted to confirm this conclusion.

## Keywords
- Pathogenesis
- Medicine
- Meta-analysis
- Pathological
- Confidence interval
- Genotype
- Diabetic retinopathy
- Disease
- Ophthalmology
- Gene polymorphism
- Subgroup analysis
- Internal medicine
- Gastroenterology
- Immunology
- Genetics
- Biology
- Gene
- Endocrinology
- Diabetes mellitus

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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