The Relationship of Soluble P-Selectin Levels to Severity in Acute Ischemic Stroke Patients

Abstract

Background: Stroke, particularly ischemic stroke, is a major global health concern and a leading cause of mortality and disability. Inflammatory markers, such as soluble P-selectin (sP-selectin), have been associated with stroke severity and outcomes. This study aimed to evaluate the relationship between sP-selectin levels and stroke severity in patients with acute ischemic stroke. Methods: This observational analytic study included 63 stroke patients and 22 controls. Patients with acute ischemic stroke were diagnosed through clinical history, physical examination, and computed tomography scans, while sP-selectin levels were measured using an ELISA kit. Stroke severity was assessed using the National Institutes of Health Stroke Scale (NIHSS). Statistical analyses were performed to determine the association between sP-selectin levels and stroke severity. Results: The mean sP-selectin level was higher in stroke patients compared to controls, but the difference was not statistically significant (19.55 vs. 16.46, p = 0.210). No significant correlation was found between sP-selectin levels and NIHSS scores at admission ( r = 0.104, p = 0.401). Discussion: While elevated sP-selectin levels are associated with stroke pathophysiology, the lack of significant findings may be due to sample size or variability in biomarker expression. The results are consistent with prior studies that did not find a direct correlation between sP-selectin levels and stroke severity in the acute phase. Conclusion: According to this study, sP-selectin may not serve as a reliable marker for acute ischemic stroke severity. Future studies should explore its role alongside other biomarkers and assess long-term outcomes to determine its clinical relevance.

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