The Relationship Between Fatty Acid Synthetase Level and Histopathological Grading in Breast Cancer Patients

Abstract

Introduction: Breast cancer is the most prevalent cancer among women and a major cause of cancer-related deaths in women globally.Fatty acid synthetase (FASN) is a crucial enzyme in neoplastic lipogenesis.Increased FASN levels are frequently observed in various breast cancers; this enzyme contributes to metabolic oncogenic processes that are vital for the growth and survival of tumor cells.This study aims to explore the correlation between FASN levels and histopathological grading in breast cancer patients in Makassar.Methods: This retrospective cohort study included 62 of luminal subtype invasive breast cancer patients from March to May 2024 at Wahidin Sudirohusodo Hospital, Makassar.Data were collected from medical records, and examination FASN levels was carried out using the ELISA method at Clinical Pathology Laboratory Faculty of Medicine Hasanuddin University Hospital.Statistical analysis were performed Fisher Extract and Mann-Withney test.ROC (Receiver Operating Characteristics) Curve were performed for determine FASN cut-off levels.Results: A total of 62 patients with breast carcinoma were included in the study.Generally, patients in the histopathological grading group of IDC presented a moderate differentiation.There were 18 cases high FASN level among the patients with high IDC histopathological grading.Conversely, 19 low FASN levels patients predominantly belonged to the well differentiation group (p value = 0.003).The degree of correlation between levels of FASN and the grading of this histopathological was 0.702 (CI95%: 0.56-0.83). Conclusions:The FASN level increases in accordance with the increase in histopathological grading of IDC.In addition, there is a significant relationship between the increase in FASN level and the increase in histopathological grading of IDC.The FASN level can be one of the promising biomarkers with fairly high sensitivity and specificity.

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