THE IMPACT OF DIAGNOSING AND TREATING SCHISTOSOMIASIS

Abstract

L'impact du diagnostic et du traitement de la schistosomiase La schistosomiase, une maladie parasitaire cause par les vers trmatodes Schistosoma, reprsente une menace considrable pour la sant mondiale, affectant plus de 800 millions de personnes dans 76 pays endmiques. Principalement cause par Schistosoma haematobium, Schistosoma japonicum et Schistosoma mansoni, la maladie se dveloppe dans les rgions o l'assainissement et les pratiques d'hygine sont inadquats. Malgr son impact significatif, les mthodes de diagnostic actuelles manquent d'accessibilit financire, de prcision et de clart, ce qui entrave l'efficacit de la lutte contre la maladie. Ce manuscrit passe en revue les diffrentes approches diagnostiques, y compris les techniques parasitologiques, immunologiques et molculaires. Il souligne la ncessit de disposer d'outils de diagnostic nouveaux, rentables et trs sensibles, en particulier dans les rgions faible transmission. Le manuscrit se penche galement sur la complexit de la gestion de la schistosomiase, qui repose principalement sur l'administration de praziquantel. Bien qu'il soit efficace, des dfis tels que les effets secondaires ABSTRACT Schistosomiasis, a parasitic disease caused by Schistosoma trematode worms, poses a substantial global health threat, affecting over 800 million individuals across 76 endemic countries. Predominantly caused by Schistosoma haematobium, Schistosoma japonicum, and Schistosoma mansoni, the disease thrives in regions with inadequate sanitation and hygiene practices. Despite its significant impact, current diagnostic methods lack affordability, precision, and straightforwardness, hindering effective disease control. This manuscript extensively reviews various diagnostic approaches, encompassing parasitological, immunological, and molecular techniques. The need for novel, cost-effective, and highly sensitive diagnostic tools, especially in low-transmission regions, is emphasized. The manuscript also delves into the complexities of managing schistosomiasis, primarily reliant on the administration of praziquantel. While effective, challenges such as side effects and potential resistance necessitate ongoing research. The combination of artemisin derivatives with praziquantel presents a promising avenue for enhanced treatment outcomes. In conclusion,

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