# The impact of CYP2D6 mediated drug–drug interaction: a systematic review on a combination of metoprolol and paroxetine/fluoxetine
> Bahar M.

URL kanonis: https://discover.unhas.ac.id/publications/the-impact-of-cyp2d6-mediated-drugdrug-interaction-a-systematic-review-on-a-comb
Jurnal / Konferensi: British Journal of Clinical Pharmacology
Tahun terbit: 2018
DOI: https://doi.org/10.1111/bcp.13741
ISSN: 03065251
Kuartil SJR: Q1
Citations: 34

## Authors
- Bahar M.

## Abstract
Despite the contradictory conclusions from the current literature, the majority of studies suggest that the DDI can lead to adverse clinical consequences. Since alternative antidepressants and beta-blockers with comparable efficacy are available, such DDIs can be avoided. Nonetheless, if prescribing the combination is unavoidable, a dose adjustment or close monitoring of the metoprolol-related side effects is necessary.

## Keywords
- Metoprolol
- Medicine
- Observational study
- Paroxetine
- Bradycardia
- Fluoxetine
- Discontinuation
- Meta-analysis
- CYP2D6
- Cochrane Library
- Pharmacodynamics
- Adverse effect
- Internal medicine
- Pharmacology
- Heart rate
- Pharmacokinetics
- Blood pressure
- Antidepressant
- Cytochrome P450
- Hippocampus
- Serotonin
- Receptor
- Metabolism

---
Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
Saat mengutip, gunakan DOI bila tersedia atau URL kanonis di atas.