# The effects of pearl oyster shell-derived bone grafts on TNF-alfa levels: An in vivo study in Cavia porcellus
> Oktawati S.

URL kanonis: https://discover.unhas.ac.id/publications/the-effects-of-pearl-oyster-shell-derived-bone-grafts-on-tnf-alfa-levels-an-in-v
Jurnal / Konferensi: Acta Marisiensis Seria Medica
Tahun terbit: 2024
DOI: https://doi.org/10.2478/amma-2024-0015
ISSN: 26687755
Kuartil SJR: Q4
Citations: 0

## Authors
- Oktawati S.

## Abstract
Abstract Objective : This study aims to assess the effect of bone graft materials derived from pearl oyster shells on the tumor necrosis factor-alpha (TNF-α) level. Methods : This research utilized a bone graft containing hydroxyapatite Pinctada maxima (HPM) powder obtained from pearl oyster shells. Material testing was conducted on 30 male guinea pigs aged 8-10 weeks, divided into three groups: the negative control group, the group treated solely with HPM, and the group treated with HPM combined with platelet-rich fibrin (PRF). Each treatment group was observed for 7 and 14 days. The results were analyzed using One-way ANOVA with a significance level of p<0.05. Results : The findings demonstrated a decrease in the average TNF-α levels across all groups. On observation days 7 and 14, the HPM group exhibited a significant difference compared to the negative control group, indicating reduced TNF-α levels. However, no significant difference was observed when comparing the HPM group with the HPM and PRF groups. Conclusions : Bone grafts derived from pearl oyster shells possess high levels of hydroxyapatite, and the addition of PRF into the bone graft effectively reduces TNF-α.

## Keywords
- Cavia
- In vivo
- Oyster
- Pearl oyster
- Pearl
- Tumor necrosis factor alpha
- Biology
- Anatomy
- Medicine
- Fishery
- Internal medicine
- Geography
- Archaeology
- Genetics
- Guinea pig

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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