# The effects of doxycycline and mannitol in inhibiting MMP-9 in traumatic brain injury in experimental Wistar rats
> Christeven R.

URL kanonis: https://discover.unhas.ac.id/publications/the-effects-of-doxycycline-and-mannitol-in-inhibiting-mmp-9-in-traumatic-brain-i
Jurnal / Konferensi: Chirurgia Turin
Tahun terbit: 2024
DOI: https://doi.org/10.23736/S0394-9508.23.05589-4
ISSN: 03949508
Kuartil SJR: Q4
Citations: 1

## Authors
- Christeven R.

## Abstract
BACKGROUND: The loss of matrix metalloproteinase-9 (MMP-9) regulation in brain trauma contributes to the pathophysiology of blood-brain barrier degradation. This study aimed at comparing MMP-9 inhibition properties of doxycycline and mannitol in brain trauma.METHODS: Model rats were used in a laboratory setting with a post-test control group design. The study was conducted at the Animal Laboratory of Hasanuddin University for two weeks. The model rats were categorized into four groups: the CONTROL group, the traumatic brain injury group (TRAUMA), the traumatic brain injury group given mannitol (TRAUMA+M), and the traumatic brain injury group given doxycycline (TRAUMA+D). The minimum number of samples required for each group was nine.RESULTS: The mean MMP-9 values of the CONTROL, TRAUMA, TRAUMA+M, and TRAUMA+D groups were 0.5193 ng/mL, 0.6101 ng/mL, 0.5522 ng/mL, and 0.5433 ng/mL, respectively. The mean MMP-9 value of the TRAUMA+M group was significantly lower than that of the TRAUMA group (P=0.017). The mean MMP-9 value of the TRAUMA+D group was also significantly lower than that of the TRAUMA group (P=0.006).CONCLUSIONS: Mannitol and doxycycline statistically significantly inhibited the increase of MMP-9 in this brain-injured Wistar rat model.

## Keywords
- Mannitol
- Doxycycline
- Traumatic brain injury
- Pharmacology
- Matrix metalloproteinase
- Medicine
- Anesthesia
- Internal medicine
- Chemistry
- Psychiatry
- Biochemistry
- Antibiotics

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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