# The effectiveness of risperidone on PANSS score and IL-6 in confirmed COVID-19 schizophrenic patients
> Lisal S.T.

URL kanonis: https://discover.unhas.ac.id/publications/the-effectiveness-of-risperidone-on-panss-score-and-il-6-in-confirmed-covid-19-s
Jurnal / Konferensi: Healthcare in Low Resource Settings
Tahun terbit: 2025
DOI: https://doi.org/10.4081/hls.2024.12723
ISSN: 22817824
Kuartil SJR: Q4
Citations: 0

## Authors
- Lisal S.T.

## Abstract
The study aimed to determine the efficacy of risperidone on PANSS scores and Interleukin 6 (IL-6) levels in schizophrenia patients with confirmed COVID-19. The study type was analytical observational, with a prospective cohort design. The subjects included inpatient Schizophrenia patients with and without COVID-19, mild-moderate and asymptomatic COVID-19, and schizophrenic patients without COVID-19 who were hospitalized and met the inclusion and exclusion criteria, for a total of 22 subjects in each group. The Positive and Negative Syndrome Scale (PANSS) and Elisa Interleukin 6 (IL-6) serum were sampled consecutively for this study. In the positive covid-19 group, the Mean IL-6 Post was significantly lower than Pre (23.0 vs. 26.1, p<0.001), while in the control group, the Mean IL-6 Post (four weeks) was significantly lower than Pre (baseline), with 19.3 vs. 21.0 (p<0.001). Serum IL-6 levels appeared to be an effective prognostic biomarker in COVID-19 patients. The 35 pg/mL cut-off point could distinguish mild-moderate patients from more severe ones. We discovered that schizophrenia patients with verified positive COVID-19 received COVID-19 therapy in the form of a combination of antipsychotic and antivirals had IL-6 levels lower than 35 pg/mL, indicating the role of antipsychotic (risperidone) and antiviral in reducing IL-6 levels.

## Keywords
- Risperidone
- Coronavirus disease 2019 (COVID-19)
- Schizophrenia (object-oriented programming)
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
- Medicine
- 2019-20 coronavirus outbreak
- Psychiatry
- Internal medicine
- Psychology
- Clinical psychology
- Virology
- Outbreak
- Disease
- Infectious disease (medical specialty)

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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