The Effect of Pumpkin Seeds (Cucurbita moschata) on Uric Acid Level in Hyperuricemia Patients

Abstract

Background: Hyperuricemia is a condition in which uric acid level exceeds normal threshold. The pumpkin seed extract contains flavonoids that can lower uric acid level. This study aims to analyze the effect of pumpkin seeds (Cucurbita moschata) capsules compared to allopurinol on uric acid level in hyperuricemia patients. Methods: This was an experimental research with a non-randomized control group pretest-posttest design. A total of 63 patients (32 intervention and 31 control) with hyperuricemia enrolled in this study through purposive sampling technique. The intervention group (IG) was given pumpkin seeds and control group (CG), allopurinol. Data were analyzed using paired and independent sample t-test. Results: The result of this study showed that uric acid level significantly decreased after the pumpkin seed capsule was provided (Mean changes=-0.33 mg,dl; P<0.001). However, allopurinol played a greater role in lowering uric acid levels (Mean changes=-0.92 mg/dl; P<0.001). The mean changes of uric acid between groups was also significant (P=0.039). In addition, some of the nutrition intakes showed a significant difference after the intervention. Conclusion: It can be concluded from the study that pumpkin seed capsules affected the decrease of uric acid level significantly, but the number was lower compared to allopurinol. In future studies, The dose of pumpkin seed should be considered.

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