# The effect of giving ascorbic acid, α-Tocopherol and its combination on superoxide anion radical, malondialdehyde levels and histopathological features in traumatic brain injuries of male albino rats of the Wistar strain
> Arief N.

URL kanonis: https://discover.unhas.ac.id/publications/the-effect-of-giving-ascorbic-acid-tocopherol-and-its-combination-on-superoxide
Jurnal / Konferensi: Gazzetta Medica Italiana Archivio Per Le Scienze Mediche
Tahun terbit: 2025
DOI: https://doi.org/10.23736/S0393-3660.24.05697-3
ISSN: 03933660
Kuartil SJR: Q4
Citations: 0

## Authors
- Arief N.

## Abstract
BACKGROUND: Traumatic brain injury (TBI) is a disorder of brain function and is a common cause of death and disability. The administration of ascorbic acid (AA) and α-Tocopherol can be useful for minimizing cell damage caused by ROS. The aim of this study was to determine the effect of administering AA, α-Tocopherol and their combination on levels of superoxide anion radicals, malondialdehyde and brain histopathological features in TBI in male Wistar albino rats.METHODS: A laboratory experimental study was done on Feeney Weight Drop model mice from January to February 2024. Divided into 4 groups, namely group A (given AA 60 mg/kg), group B (given α-Tocopherol 60 mg/kg), group C (given a combination of AA and α-Tocopherol 60 mg/kg) and group D as positive control (given NaCl 0.9%).RESULTS: As many as 24 experimental mice were obtained. Increase in superoxide anion radical (SAR) inhibition levels and decrease in malondialdehyde (MDA) levels in the group of mice given AA and α-Tocopherol post 3 hours and post 24 hours compared to the control (P<0.05). The combination of AA and α-Tocopherol showed the highest increase of SAR inhibition levels and greatest reduction of MDA (P>0.05). The histopathological picture with the most severe was found in the control group and mild score in the group C.CONCLUSIONS: Administration of AA and α-Tocopherol was proven to reduce oxidative stress caused by superoxide anion radicals and provide neuroprotective effects in rats treated with TBI. Further study was needed.

## Keywords
- Malondialdehyde
- Ascorbic acid
- Superoxide
- Tocopherol
- Chemistry
- Strain (injury)
- Biochemistry
- Internal medicine
- Antioxidant
- Medicine
- Vitamin E
- Food science
- Enzyme

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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