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The effect of giving ascorbic acid, α-Tocopherol and its combination on superoxide anion radical, malondialdehyde levels and histopathological features in traumatic brain injuries of male albino rats of the Wistar strain
Arief N.
Gazzetta Medica Italiana Archivio Per Le Scienze Mediche
Q4Abstract
BACKGROUND: Traumatic brain injury (TBI) is a disorder of brain function and is a common cause of death and disability. The administration of ascorbic acid (AA) and α-Tocopherol can be useful for minimizing cell damage caused by ROS. The aim of this study was to determine the effect of administering AA, α-Tocopherol and their combination on levels of superoxide anion radicals, malondialdehyde and brain histopathological features in TBI in male Wistar albino rats.METHODS: A laboratory experimental study was done on Feeney Weight Drop model mice from January to February 2024. Divided into 4 groups, namely group A (given AA 60 mg/kg), group B (given α-Tocopherol 60 mg/kg), group C (given a combination of AA and α-Tocopherol 60 mg/kg) and group D as positive control (given NaCl 0.9%).RESULTS: As many as 24 experimental mice were obtained. Increase in superoxide anion radical (SAR) inhibition levels and decrease in malondialdehyde (MDA) levels in the group of mice given AA and α-Tocopherol post 3 hours and post 24 hours compared to the control (P<0.05). The combination of AA and α-Tocopherol showed the highest increase of SAR inhibition levels and greatest reduction of MDA (P>0.05). The histopathological picture with the most severe was found in the control group and mild score in the group C.CONCLUSIONS: Administration of AA and α-Tocopherol was proven to reduce oxidative stress caused by superoxide anion radicals and provide neuroprotective effects in rats treated with TBI. Further study was needed.