Testing the Effectiveness of Dayak Onion Extract (Eleutherine palmifolia (L) On Mucosa Gastroprotective Activitygumble and Histopathology of Male Mouse (Mus Musculus) Which Is Induced Aspirin

Abstract

Gastroprotective treatment can use single oral synthetic drugs.Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) that is often used to relieve or eliminate pain in the treatment of osteoarthritis and rheumatoid arthritis.In general, people use traditional medicine, along with synthetic medicine.Dayak onions are herbal plants that are widely used to treat pain.This study aims to provide information about the effectiveness of Dayak onion extract (eleuthero palmifolia (l) on the gastroprotective activity of the gastric mucosa and histopathology of male mice (mus musculus) induced by aspirin and information about the organ protection of mice that experience gastroprotection.Thirty mus musculus mice were divided into six groups, namely: normal control group (KN), negative control group (K-), positive control group (K+ ), and the 1% Dayak onion treatment group (KBD), the 5% Dayak onion treatment group (KBD), the 10% Dayak onion treatment (KBD) 1X1 for four days, and aspirin induction for eight days to create an ulcer mouse model.Treatment was reviewed from body weight and after intervention, as well as gastric histology.After the intervention, the K+ group, control -and Dayak onion extract 1x1, and showed damage to the mice's stomachs (<0.05) compared to the sick group, given control and extract concentrations of 1%, 5%, the best was extract with a concentration of 10%, So the higher the concentration given with the extract, the better, based on the histopathological picture.Dayak onions with an interval of 1 x 1 administration for four days work synergistically in improving the condition of gastric tissue; therefore, giving Dayak onions can be an option as a gastroprotective activity of the gastric mucosa.

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