# Synthesis of Remdesivir Derivate as a Generation of Anti-COVID-19 Drugs Through Acetylation Reactions
> Sumardi R.

URL kanonis: https://discover.unhas.ac.id/publications/synthesis-of-remdesivir-derivate-as-a-generation-of-anti-covid-19-drugs-through
Jurnal / Konferensi: Archives of Razi Institute
Tahun terbit: 2023
DOI: https://doi.org/10.32592/ARI.2023.78.6.1753
ISSN: 03653439
Kuartil SJR: Q2
Citations: 0

## Authors
- Sumardi R.

## Abstract
Remdesivir, a competitive inhibitor of viral RNA-dependent RNA polymerase, is the drug of choice for anti-COVID-19 treatment. However, the instability of these substances in plasma raises doubts about their therapeutic potency. Additionally, SARS-CoV-2-infected cells may exhibit a variety of antiviral behaviors due to intricate activation pathways. Therefore, this study aimed to develop a synthesis for the remdesivir derivative. The remdesivir derivative was synthesized using acetyl chloride as a reagent in a ratio of 1:3 in dichloromethane and tetrahydrofuran solvent at 30°C for 6 h. Thin-layer chromatography and spectrophotometers (1H NMR and 13C NMR) were used to identify the produced molecule, which was a brownish-yellow crystalline powder. The results of the synthesis yielded 0.8 gr (77.34%), and the Rf value of the remdesivir derivate was 0.54. The characterization with 1H NMR at δ2.5 ppm (3H, s) indicated the presence of a proton in the H-C-C=O structure caused by the substitution of the acetyl group in the remdesivir structure. The 13C NMR data indicated the presence of aromatic carbons, alkenes, C≡N, and carbon bonds with electronegative O. This remdesivir derivate chemical can be a potential candidate for an anti-COVID-19 drug that has more potency because it has substitutions of acetyl groups at positions 2' and 3' in the structure of remdesivir.

## Keywords
- Dichloromethane
- Chemistry
- Diazomethane
- Reagent
- Proton NMR
- Solvent
- Tetrahydrofuran
- Derivative (finance)
- Potency
- Carbon-13 NMR
- Nuclear magnetic resonance spectroscopy
- Stereochemistry
- Medicinal chemistry
- Organic chemistry
- In vitro
- Biochemistry
- Economics
- Financial economics

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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