# Synthesis of Ionophore from p-t-Butyl-(carboxymethoxy)calix[4]arene Substituted Amide
> Dali N.

URL kanonis: https://discover.unhas.ac.id/publications/synthesis-of-ionophore-from-p-t-butyl-carboxymethoxycalix4arene-substituted-amid
Jurnal / Konferensi: Molekul
Tahun terbit: 2023
DOI: https://doi.org/10.20884/1.jm.2023.18.1.5927
Kuartil SJR: Q4
Citations: 3

## Authors
- Dali N.

## Abstract
The ionophore has been successfully synthesized from p-t-butyl(carboxymethoxy)calix[4]arene subtituted amide. The ionophore was obtained in two steps of the synthesis reaction. The first step is the chlorination reaction of p-t-butyl(carboxymethoxy)calix[4]arene with thionyl chloride in dry benzene solvent. The product of the chlorination reaction is p-t-butyl(chloroacetylmethoxy)calix[4]arene in the form of the light brown viscous liquid with the rendemen of 78.25% and TLC (SiO2, CH3OH : CH2Cl2 = 1 : 1 v/v, Rf = 0.65). The second step is the amidation reaction of p-t-butyl(chloroacetylmethoxy) calix[4]arene with dimethylamine in dry tetrahydrofuran solvent. The product of the amidation reaction is p-t-butyl(dimethylcarbamoylmethoxy)-calix[4]arene or the DIMECAC4ND3 ionophore in the form of white solid with the rendemen of 60.75%, a melting point of 277-279 °C, and TLC (SiO2, CH3OH : CH2Cl2 = 1 : 1 v/v, Rf = 0.82).

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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