# Synthesis, Molecular Mechanism and Pharmacokinetic Studies of New Epoxy Lignan-Based Derivatives
> Rifai Y.

URL kanonis: https://discover.unhas.ac.id/publications/synthesis-molecular-mechanism-and-pharmacokinetic-studies-of-new-epoxy-lignan-ba
Jurnal / Konferensi: Archiv Der Pharmazie
Tahun terbit: 2016
DOI: https://doi.org/10.1002/ardp.201600069
ISSN: 03656233
Kuartil SJR: Q2
Citations: 6

## Authors
- Rifai Y.

## Abstract
The oxidative demethylation procedure for a new epoxy lignan isolated from Piper nigrum was applied to the synthesis of 3’‐methoxy‐3”,4”‐(methylenedioxy)‐2,5‐epoxylignan‐4’‐ol‐6’‐one. This compound inhibited the mRNA expression of the protein patched homolog (Ptch) in human pancreatic cancer cells (PANC1) and therefore might be valuable as a probe for tumor‐related disease. The pharmacokinetic profile of 3'‐methoxy‐3”,4”‐(methylenedioxy)‐2,5‐epoxylignan‐4'‐ol‐6'‐one was rapidly determined using ultra‐fast liquid chromatography. The compound was rapidly absorbed in blood.

## Keywords
- Lignan
- Methylenedioxy
- Chemistry
- Pharmacokinetics
- Demethylation
- Sesamin
- Pharmacology
- Stereochemistry
- Biochemistry
- Organic chemistry
- Gene expression
- Gene
- Medicine
- DNA methylation
- Halogen
- Food science
- Alkyl

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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