Synthesis and x-ray crystallographic study of n,n’-bis(2-, 3-, and 4-methoxybenzamidothiocarbonyl) hydrazines

Abstract

Objective: To investigate the one-pot reaction of 2, 3, and 4-methoxybenzoyl chloride with ammonium thiocyanate and hydrazine in acetone by reflux condition.Methods: Each of the crystal compounds was analysed by X-ray crystallography.Result: Three compound of bis-thiorea derivatives, namely N, N'-bis (2-methoxy-benzamidothiocarbonyl) hydrazine (1), N, N'bis (3-methoxybenzamidothiocarbonyl) -hydrazine (2), and N, N' -bis (4-methoxybenzamidothiocarbonyl) hydrazine (3) were successfully synthesised by the reaction of each 2, 3, and 4-methoxybenzoyl chloride with ammonium thiocyanate and hydrazine in acetone.The structure of these compounds was studied by chemical crystallography.Conclusion: Compound 1 and 3 were crystallized in the triclinic crystal system while compound 2 was crystallized in the monoclinic crystal system.The thiourea moiety in all compounds have trans geometry and each of the hydrogens of the amide group is trans to the carbonyl group.

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