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Synthesis and Anti-tuberculosis Potential of Fe(II)Tyrosine Complex
Filbert F.
Aip Conference Proceedings
Abstract
Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis (M. tuberculosis) bacteria. World Health Organization has stated that the case has increased by almost 10 million worldwide in 2019 year-round. Tuberculosis may be treated using an antibiotic medicine. Unfortunately, 4,578 patients in Indonesia showed resistant symptoms for this first-lined medicine. A brand-new medicine is needed to treat tuberculosis disease more effectively. Complexes compound that could be used as an anti-tuberculosis agent has been studied as an alternative tuberculosis medicine precursor. Research about complexes Fe(II)Tyrosine synthesis has been conducted using the direct pressing method under molar reaction ratio 1:3 ethanol solvent. The synthesized complexes compound was characterized using UV-Visible (UV-Vis) spectrophotometry, Fourier-Transform Infrared (FT-IR) spectroscopy, melting point test, and conductometry. Complex Fe(II)Tyrosine showed electronic transition at 513 nm contributes to π-π* electronic transition from metal-ligan interaction. FT-IR spectra showed absorption paths at wave number 352.97 cm−1 for v(M-O) area and 322.11 cm−1 for v(M-N) area. Characterization using UV-Vis spectrophotometry, FT-IR spectroscopy, melting point test, and conductometry showed that complexes Fe(II)Tyrosine had been successfully synthesized. In vitro study showed that Fe(II)Tyrosine has the potential as an anti-tuberculosis agent.