# Structural assessment of chemical constituent of sidaguri (Sida rhombifolia linn) and its ability to inhibit cyclooxygenase
> Tanumihadja M.

URL kanonis: https://discover.unhas.ac.id/publications/structural-assessment-of-chemical-constituent-of-sidaguri-sida-rhombifolia-linn
Jurnal / Konferensi: Pesquisa Brasileira Em Odontopediatria E Clinica Integrada
Tahun terbit: 2019
DOI: https://doi.org/10.4034/PBOCI.2019.191.96
ISSN: 15190501
Kuartil SJR: Q2
Citations: 7

## Authors
- Tanumihadja M.

## Abstract
Objective: To elicit the structure of isolated compounds from roots of sidaguri ( Sida rhombifolia Linn).  Material and Methods: Several organic standard protocols were involved, including extraction, fractionation, and phytochemical testing. Further spectroscopy methods, FTIR and 1HNMR, were used to determine the predicted structure of molecules, while their ability to inhibit cyclooxygenase (COX 1 and 2) were tested using in vitro method.  Results: Overall assessments showed that the structure of the sidaguri is a long chain aliphatic carboxylic acid and identified as Z-3, 6, 6 trimethylhept-2-en-1-ol (T12) and nonanoic (T13). Both isolates significantly inhibit COX-1 and COX-2 non-selectively (the COX-1/COX-2 ratio for T12 was 0.91 and 0.82; while COX-1/COX-2 ratio for T13 was 0.89 and 0.87 at concentrations of 0.05 and 0.025 µg/mL respectively).  Conclusion: The active compounds of Sidaguri have anti-inflammatory effect by inhibiting COX non-selectively.

## Keywords
- Cyclooxygenase
- Traditional medicine
- Human immunodeficiency virus (HIV)
- Chemistry
- Quality assessment
- Medicine
- Virology
- Biochemistry
- Enzyme
- External quality assessment
- Pathology

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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