# Staphylococcal protein a is a key factor in neutrophil extracellular traps formation
> Hoppenbrouwers T.

URL kanonis: https://discover.unhas.ac.id/publications/staphylococcal-protein-a-is-a-key-factor-in-neutrophil-extracellular-traps-forma
Jurnal / Konferensi: Frontiers in Immunology
Tahun terbit: 2018
DOI: https://doi.org/10.3389/fimmu.2018.00165
ISSN: 16643224
Kuartil SJR: Q1
Citations: 39

## Authors
- Hoppenbrouwers T.

## Abstract
<i>Staphylococcus aureus</i> are strong inducers of neutrophil extracellular traps (NETs), a defense mechanism of neutrophils against pathogens. Our aim was to explore the role of Protein A in <i>S. aureus</i>-induced NETosis. We determined the Protein A production of four different <i>S. aureus</i> strains and found a direct relationship between the degree of NETosis induction and Protein A production: strains producing higher concentrations of Protein A evoke significantly more NETs. A <i>S. aureus</i> strain in which Protein A as well as a second binding protein for immunoglobulins (<i>Sbi</i>) have been knocked-out (Δ<i>SpA</i> Δ<i>Sbi</i>) induced significantly less NETosis than the wild-type strain. NETosis induction by this knockout strain can be rescued by the addition of purified Protein A. Dead <i>S. aureus</i> did not induce NETosis. In conclusion, Protein A is a determinant for NETosis induction by <i>S. aureus</i>.

## Keywords
- Neutrophil extracellular traps
- Staphylococcus aureus
- Microbiology
- Strain (injury)
- Protein A
- Extracellular
- Antibody
- Biology
- Chemistry
- Immunology
- Bacteria
- Inflammation
- Cell biology
- Genetics
- Anatomy

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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