# Sexual dimorphism in sars-cov-2 infection
> Ulhaq Z.S.

URL kanonis: https://discover.unhas.ac.id/publications/sexual-dimorphism-in-sars-cov-2-infection
Jurnal / Konferensi: Acta Endocrinologica
Tahun terbit: 2020
DOI: https://doi.org/10.4183/aeb.2020.522
ISSN: 18410987
Kuartil SJR: Q4
Citations: 5

## Authors
- Ulhaq Z.S.

## Abstract
Previous studies have demonstrated that female patients with coronavirus disease 2019 (COVID-19) demonstrate more favorable prognosis relative to male patients. In this article, we elaborate the possible role of estrogen in the modulation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection severity. The potential interplay between several factors, including inherently lower estradiol (E<sub>2</sub>) and slightly higher estrogen receptor β (ERβ) levels in males, with inflammatory mediators are described. Altogether, there seems to be a sexually dimorphic response towards SARS-CoV-2 infection, and a possibility that COVID-19 severity is dependent on both E<sub>2</sub> levels and ERα:ERβ expression ratio in lymphoid and lung cells.

## Keywords
- Sexual dimorphism
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
- Coronavirus disease 2019 (COVID-19)
- Virology
- 2019-20 coronavirus outbreak
- Biology
- Sars virus
- Betacoronavirus
- Coronavirus Infections
- Medicine
- Zoology
- Outbreak
- Pathology
- Infectious disease (medical specialty)
- Disease

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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