# Salivary alpha amylase enzyme and salivary cortisol level in depression after treatment with fluoxetine
> Tanra A.J.

URL kanonis: https://discover.unhas.ac.id/publications/salivary-alpha-amylase-enzyme-and-salivary-cortisol-level-in-depression-after-tr-1
Jurnal / Konferensi: Open Access Macedonian Journal of Medical Sciences
Tahun terbit: 2021
DOI: https://doi.org/10.3889/oamjms.2021.6278
ISSN: 18579655
Citations: 1

## Authors
- Tanra A.J.

## Abstract
BACKGROUND: Hypothalamic-pituitary-adrenal axis and its end product cortisol have been extensively investigated in patients with depressive disorders for many years. Recently, salivary alpha-amylase (sAA) had emerged as a new biomarker with non-invasive and more convenience protocol for measuring sympathetic activity which were also associated with depression. Selective Serotonin Reuptake Inhibitor is antidepressant drug extensively used to treat depression. AIM: The aim of this study was to determine whether decrease of sAA and salivary cortisol levels could be observed in subjects with depression who were treated by fluoxetine. METHODS: The total subjects were 25 depressed subjects and ten healthy controls. sAA was examined before therapy, and after 2, 4, and 6 weeks of fluoxetine administration using a portable cocorometer. Salivary cortisol was examined before therapy, after 4 and 6 weeks of fluoxetine administration with Elisa method. The therapeutic effect was assessed with Hamilton Depression Rating Scale (HDRS). RESULTS: sAA and cortisol levels were significantly decreased after fluoxetine administration (p < 0.001), followed by at least 50% reduction of HDRS scores after 6 weeks of fluoxetine administration. Levels of sAA and cortisol were higher in the depression group than in the healthy control. CONCLUSIONS: Measurement of sAA levels can be used as a potential biomarker of therapeutic response in depressed patients in addition to salivary cortisol.

## Keywords
- Fluoxetine
- Medicine
- Internal medicine
- Serotonin reuptake inhibitor
- Antidepressant
- Depression (economics)
- Endocrinology
- Biomarker
- Hydrocortisone
- Reuptake inhibitor
- Serotonin
- Receptor
- Economics
- Biochemistry
- Chemistry
- Macroeconomics
- Hippocampus

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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