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Universitas Hasanuddin
Research output:Contribution to journal›Article›peer-review

Remdesivir and its antiviral activity against COVID-19: A systematic review

Frediansyah A.

Clinical Epidemiology and Global Health

Q2
Published: 2021Citations: 180

Abstract

BACKGROUND: The aim of this study was to summarize the antiviral activities of remdesivir against SARS-CoV-2, the causative agent of COVID-19. METHODS: Available publications were systematically explored on some databases and gray literature was examined. Publications were discussed narratively. RESULTS: Remdesivir inhibits SARS-CoV-2 replication, reduces viral load, and exerts protective effects in SARS-CoV-2 infected animals. Remdesivir also reduces the pathological process, alleviates mild symptoms, and improves pulmonary lesions in SARS-CoV-2-infecetd animals. Remdesivir has been used as a compassionate drug for treating COVID-19 patients. CONCLUSION: Although remdesivir has shown potent antiviral activities, more efficacy assessments are urgently warranted in clinical trials.

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10.1016/j.cegh.2020.07.011

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Coronavirus disease 2019 (COVID-19)Sciences
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Sciences
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