# Relationship of HER2 and PD-L1 expression with clinicopathology in gastric cancer: a cross-sectional study
> Mappaodang A.

URL kanonis: https://discover.unhas.ac.id/publications/relationship-of-her2-and-pd-l1-expression-with-clinicopathology-in-gastric-cance
Jurnal / Konferensi: Chirurgia Turin
Tahun terbit: 2025
DOI: https://doi.org/10.23736/S0394-9508.25.05857-7
ISSN: 03949508
Kuartil SJR: Q4
Citations: 0

## Authors
- Mappaodang A.

## Abstract
BACKGROUND: Gastric cancer is a major global health concern with a poor prognosis. Human epidermal growth factor receptor 2 (HER2) and programmed cell death 1 ligand 1 (PD-L1) are biomarkers associated with tumor progression and immune escape, respectively. This study investigated the relationship between HER2 and PD-L1 expression and clinicopathological features in patients with gastric cancer in Makassar, Indonesia.METHODS: A cross-sectional study was conducted involving patients diagnosed with gastric cancer. HER2 and PD-L1 expression were quantified immunohistochemically and correlated with age, sex, cancer staging, histopathological grading, and tumor resectability.RESULTS: Among 34 patients, HER2 was positively expressed in 15% and PD-L1 in 40%. HER2 expression was significantly correlated with advanced cancer stage and poor histopathological grade (P<0.05). PD-L1 expression was significantly associated with tumor resectability (P<0.05). HER2 and PD-L1 expression was not significantly correlated with age or sex.CONCLUSIONS: HER2 and PD-L1 play distinct roles in the clinicopathological landscape of gastric cancer and could serve as prognostic indicators and therapeutic targets. Further research with larger cohorts is recommended.

## Keywords
- Immunohistochemistry
- Cancer
- Medicine
- Stage (stratigraphy)
- Pathology
- Human Epidermal Growth Factor Receptor 2
- Immune system
- Receptor
- Oncology
- Epidermal growth factor receptor
- Internal medicine
- Tumor progression
- Cancer research
- Over expression
- Histopathology
- Expression (computer science)
- Stomach
- Cancer cell
- Cell
- Tumor stage
- Metastasis
- HER2/neu
- Epidermal growth factor
- Trastuzumab

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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