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Relationship of HER2 and PD-L1 expression with clinicopathology in gastric cancer: a cross-sectional study
Mappaodang A.
Chirurgia Turin
Q4Abstract
BACKGROUND: Gastric cancer is a major global health concern with a poor prognosis. Human epidermal growth factor receptor 2 (HER2) and programmed cell death 1 ligand 1 (PD-L1) are biomarkers associated with tumor progression and immune escape, respectively. This study investigated the relationship between HER2 and PD-L1 expression and clinicopathological features in patients with gastric cancer in Makassar, Indonesia.METHODS: A cross-sectional study was conducted involving patients diagnosed with gastric cancer. HER2 and PD-L1 expression were quantified immunohistochemically and correlated with age, sex, cancer staging, histopathological grading, and tumor resectability.RESULTS: Among 34 patients, HER2 was positively expressed in 15% and PD-L1 in 40%. HER2 expression was significantly correlated with advanced cancer stage and poor histopathological grade (P<0.05). PD-L1 expression was significantly associated with tumor resectability (P<0.05). HER2 and PD-L1 expression was not significantly correlated with age or sex.CONCLUSIONS: HER2 and PD-L1 play distinct roles in the clinicopathological landscape of gastric cancer and could serve as prognostic indicators and therapeutic targets. Further research with larger cohorts is recommended.