# Relationship between interleukin-6 levels and the degree of hearing loss in chronic suppurative otitis media: a cross-sectional study
> Astrib D.

URL kanonis: https://discover.unhas.ac.id/publications/relationship-between-interleukin-6-levels-and-the-degree-of-hearing-loss-in-chro
Jurnal / Konferensi: Gazzetta Medica Italiana Archivio Per Le Scienze Mediche
Tahun terbit: 2025
DOI: https://doi.org/10.23736/S0393-3660.24.05726-7
ISSN: 03933660
Kuartil SJR: Q4
Citations: 0

## Authors
- Astrib D.

## Abstract
BACKGROUND: The morbidity of chronic suppurative otitis media (CSOM) is advanced in patients with cholesteatoma. Cholesteatoma is a suitable medium for bacterial growth and could trigger an infection and inflammation process characterized by increased levels of interleukin (IL)-6. The aim of this study was to determine the relationship between IL-6 levels and the degree of hearing loss and deafness in CSOM patients with or without cholesteatoma.METHODS: This study used a cross-sectional design on 42 eligible CSOM patients with cholesteatoma (group A, N.=21) and without cholesteatoma (group B, N.=21). In each group, the tympanic room samples were taken during surgery to examine IL-6 levels using the ELISA method. In addition, the degree of hearing loss and deafness was assessed through a pure tone audiometry (PTA) examination. The Spearman correlation test and simple linear regression analyzed the data.RESULTS: Both groups had the same baseline characteristics regarding gender, age, and degree of deafness. IL-6 levels did not differ between groups A and B (118.76 [64.42-196.70] ng/mL vs. 121.22 [3.48-304.95] ng/mL, P=0.990). There was no significant correlation between the degree of deafness and IL-6 levels in groups A and B (r=0.229; P=0.317 and r=-0.384; P=0.086). Although the audiogram value in group A was higher than group B, the two were not significantly different (P=0.420). Furthermore, IL-6 levels could not be a significant determinant of the audiogram value in the simple linear regression model (B=-0.002, P=0.252).CONCLUSIONS: IL-6 levels cannot be a determined factor of hearing loss in patients with CSOM with or without cholesteatoma.

## Keywords
- Audiogram
- Medicine
- Chronic Suppurative Otitis Media
- Cholesteatoma
- Audiology
- Hearing loss
- Audiometry
- Pure tone audiometry
- Degree (music)
- Correlation
- Epidemiology
- Otorhinolaryngology
- Linear regression
- Ear disease
- Middle ear
- Otitis
- Predictive value
- Internal medicine
- Regression analysis
- Acute otitis media
- Risk factor
- Confounding
- Surgery
- Tympanum (architecture)
- Absolute threshold of hearing

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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