Receptor agonist of NFjB signaling ligand directs lung epithelial cell expansion through RANK signaling

Abstract

This study describes for the first time a role for bone cytokine RANKL in lung epithelial repair following lung damage. Using both murine and human models, we describe how RANKL-mediated signaling promotes epithelial expansion by acting on epithelial transitional cell states. For diseases with substantial lung damage, modulating RANKL signaling during the early repair phase following lung injury could represent a strategy to enhance epithelial regeneration.

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