# Randomized control trial outcomes of tranexamic acid combination serum as a depigmenting agent for the use in healthy individuals
> Anwar A.I.

URL kanonis: https://discover.unhas.ac.id/publications/randomized-control-trial-outcomes-of-tranexamic-acid-combination-serum-as-a-depi
Jurnal / Konferensi: Dermatologic Therapy
Tahun terbit: 2019
DOI: https://doi.org/10.1111/dth.13146
ISSN: 13960296
Kuartil SJR: Q1
Citations: 12

## Authors
- Anwar A.I.

## Abstract
To compare the effectiveness of tranexamic acid (TA) combination serum with hydroquinone, the gold standard in whitening agents for healthy populations. This was a three-arm randomized controlled trial. The subjects were divided into three groups: the first group received 3% TA combination serum (3% TA, 4% galactomyces ferment filtrate, 2% niacinamide, and 4% alpha arbutin), the second group received 2% TA combination serum, and the third group received 4% hydroquinone. One milliliter of each serum was applied on three holes: Hole A, which was located 4 cm from the left cubital fossa, Hole B, which was located 4 cm from the first hole, and Hole C, which was located 4 cm from the right cubital fossa. The skin brightness and pigmentation intensity were evaluated each week for 4 weeks using a chromameter. A total of 44 subjects were recruited for this study. All groups showed a significant improvement in skin brightness and pigmentation intensity after 4 weeks (p < .001). There were no differences between the treatment groups and hydroquinone (p > .05). TA serum (2 and 3%) combined with 4% galactomyces ferment filtrate, niacinamide, and alpha arbutin is an effective depigmenting agent.

## Keywords
- Medicine
- Tranexamic acid
- Randomized controlled trial
- Arbutin
- Niacinamide
- Surgery
- Hydroquinone
- Gastroenterology
- Urology
- Blood loss
- Chromatography
- Biochemistry
- Nicotinamide
- Enzyme
- Chemistry

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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