Analysis of the Relationship Between Soluble Cd40 Ligand and Homeostasis Model Assessment of Insulin Resistance in Obese Non-Diabetic Subjects

Abstract

Obesity is a complex multifactorial disease characterized by the accumulation of body fat, leading to adverse effects on one’s well-being. Obesity has a strong association with insulin resistance. Insulin resistance can lead to a range of health issues, including type II diabetes mellitus, cardiovascular disease, and other metabolic syndrome diseases. A method that can be employed to evaluate insulin resistance is the measurement of HOMA-IR. sCD40L is the soluble form of the CD40L molecule released on the cell surface through proteolysis. There is evidence that the sCD40L level is a strong predictor of cardiovascular risk, and enhanced levels of CD40L were reported in patients with hypercholesterolemia, diabetes mellitus, and acute coronary syndromes.

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