# The Potential of PD-1 and PD-L1 as Prognostic and Predictive Biomarkers in Colorectal Adenocarcinoma Based on TILs Grading
> Rasyid N.R.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_85213478645
Jurnal / Konferensi: Current Oncology
Tahun terbit: 2024
DOI: https://doi.org/10.3390/curroncol31120552
ISSN: 17187729
Kuartil SJR: Q2
Citations: 2

## Authors
- Rasyid N.R.

## Abstract
AIM: Colorectal cancer (CRC) is a prevalent malignancy with a high mortality rate. Tumor-infiltrating lymphocytes (TILs) play a crucial role in the immune response against tumors. Programmed death-1 (PD-1) and programmed death-ligand 1 (PD-L1) are key immune checkpoints regulating T cells in the tumor microenvironment. This study aimed to assess the relationships among PD-1 expression on TILs, PD-L1 expression in tumors, and TIL grading in colorectal adenocarcinoma. METHODS: A cross-sectional design was employed to analyze 130 colorectal adenocarcinoma samples. The expression of PD-1 and PD-L1 was assessed through immunohistochemistry. A semi-quantitative scoring system was applied. Statistical analysis with the chi-square test was performed to explore correlations, with the data analyzed in SPSS version 27. RESULTS: < 0.001). CONCLUSIONS: The expression of PD-1 on TILs and PD-L1 on tumor cells correlated significantly with the grading of TILs in colorectal adenocarcinoma. This finding shows potential as a predictive biomarker for PD-1/PD-L1 blockade therapy. Further studies are needed to strengthen these results.

## Keywords
- Medicine
- Grading (engineering)
- Colorectal cancer
- Malignancy
- Oncology
- Tumor-infiltrating lymphocytes
- PD-L1
- Adenocarcinoma
- Immunohistochemistry
- Colorectal adenocarcinoma
- Internal medicine
- Tumor microenvironment
- Immunotherapy
- Cancer research
- Cancer
- Biology
- Ecology

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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