# A novel approach using urinary fibronectin to assess the severity of preeclampsia: a cross-sectional study
> Hidayatullah M.S.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_85203662713
Jurnal / Konferensi: Gazzetta Medica Italiana Archivio Per Le Scienze Mediche
Tahun terbit: 2024
DOI: https://doi.org/10.23736/S0393-3660.23.05219-1
ISSN: 03933660
Kuartil SJR: Q4
Citations: 0

## Authors
- Hidayatullah M.S.

## Abstract
BACKGROUND: Around the world, 5-10% of pregnancies are affected with preeclampsia, which increases maternal morbidity and mortality. Fibronectin can be found in the blood of preeclampsia women. Although these biomarkers can also be identified in the urine, the study investigating its relationship with preeclampsia is still limited. The aim of this study was to evaluate the relationship between preeclampsia and urine fibronectin.METHODS: A cross-sectional study design was conducted and involving all eligible pregnant women without preeclampsia and preeclampsia at Wahidin Sudirohusodo Hospital, Siti Khadijah 1 Mother and Child Hospital, RSKDIA Fatimah Hospital and RSKDIA Pertiwi Hospital. Sampling was done by simple random sampling. Urine samples were taken to measure fibronectin levels using the ELISA method. The differences in fibronectin levels between the preeclampsia and non-preeclampsia groups were examined using the independent t-test.RESULTS: Of the 130 subjects consisting of preeclampsia (N.=65) and not preeclampsia (N.=65), the majority were aged 20-35 years, had education >9 years, did not work, were multigravida, and had a family history of preeclampsia and hypertension. The levels of fibronectin in the preeclampsia and non-preeclampsia groups did not differ significantly (148.19±47.52 ng/mL vs. 161.86±48.65 ng/mL, P=0.108). However, compared to the non-preeclampsia group, the preeclampsia group’s platelet count was lower (216,795.38±57,348.79 vs. 253,344.62±81,424.97; P=0.003).CONCLUSIONS: Urinary fibronectin levels are not associated with preeclampsia. Further studies must be conducted to obtain the exact benefit of fibronectin as a biomarker for preeclampsia.

## Keywords
- Cross-sectional study
- Preeclampsia
- Urinary system
- Medicine
- Obstetrics
- Internal medicine
- Pregnancy
- Biology
- Pathology
- Genetics

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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