# Comparison of interleukin 6 levels in patients with Hirschsprung-associated enterocolitis based on histopathological grade
> Husni M.A.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_85203366915
Jurnal / Konferensi: Chirurgia Turin
Tahun terbit: 2024
DOI: https://doi.org/10.23736/S0394-9508.24.05697-3
ISSN: 03949508
Kuartil SJR: Q4
Citations: 2

## Authors
- Husni M.A.

## Abstract
BACKGROUND: Hirschsprung-associated enterocolitis (HAEC) is a major cause of morbidity and mortality in patients with Hirschsprung’s disease (HD). Bacteria that penetrate the body’s epithelial surface induce macrophages to secrete cytokines, including interleukin (IL)-6. This study aimed to compare IL-6 levels in patients with HD with or without HAEC based on their histopathological grade according to Teitelbaum’s criteria.METHODS: This cross-sectional study involved 15 children with HD with or without HAEC. It used the Delphi method to establish the HAEC diagnosis. IL-6 levels in blood samples were determined by enzyme-linked immunosorbent assay.RESULTS: While IL-6 levels differed between those with and without HAEC (212.00±366.53 and 46.64±0.00, respectively), the difference was nonsignificant (P=0.165). However, IL-6 levels were significantly positively correlated with the HAEC histopathology grade (Spearman’s r=0.844, P<0.001).CONCLUSIONS: A strong positive correlation exists between the HAEC histopathological grade and IL-6 levels. Therefore, checking IL-6 levels in children with suspected HAEC could be helpful for earlier diagnosis and treatment, reducing their morbidity.

## Keywords
- Medicine
- Hirschsprung's disease
- Enterocolitis
- Gastroenterology
- Internal medicine
- Disease

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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