# A Literature Review: Relationship between Interleukin-1 Beta and the Severity of COVID-19
> Maghfirah A.I.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_85196515848
Jurnal / Konferensi: Indonesian Journal of Clinical Pathology and Medical Laboratory
Tahun terbit: 2024
DOI: https://doi.org/10.24293/ijcpml.v30i3.2255
ISSN: 24774685
Kuartil SJR: Q4
Citations: 0

## Authors
- Maghfirah A.I.

## Abstract
COVID-19 disease can cause dysregulation of the immune system, resulting in a cytokine storm. One of the cytokines released is IL-1B, a proinflammatory cytokine due to macrophage stimulation. This study aimed to provide a literature review of the value of Interleukin-1 beta (IL-1B) in patients with severity of COVID-19. This literature review was carried out using the search engines PubMed, Open Accessed Journal, Science Direct, and Google Scholar from December 2019 to December 2022. No studies suggested that IL-1B was associated with the severity of COVID-19. IL-1B is vital during the acute inflammatory response and helps T cells by linking innate and adaptive immunity as a lymphocyte activation factor. A gradual decrease in lymphocyte count was reported in severe COVID-19 diseases. The substantial reduction in lymphocyte count indicates that the SARS-CoV-2 virus increases immune cells and inhibits cellular immunity. This result might explain why IL-1B levels in mild COVID-19 were not significantly different from IL-1B levels in severe COVID-19. There was an increase in IL-1B levels in COVID-19 patients, but there was no relationship between IL-1B and the severity of COVID-19.

## Keywords
- Medicine
- Coronavirus disease 2019 (COVID-19)
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
- 2019-20 coronavirus outbreak
- Interleukin
- Internal medicine
- Virology
- Cytokine
- Outbreak
- Disease
- Infectious disease (medical specialty)

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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