# Cyclic Sesquiterpene-Flavanone [4+2] Hybrids, Syzygioblanes A-C, Found in an Indonesian Traditional Medicine, “Jampu Salo” (Syzygium oblanceolatum)
> Koga N.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_85192864542
Jurnal / Konferensi: Organic Letters
Tahun terbit: 2024
DOI: https://doi.org/10.1021/acs.orglett.4c01248
ISSN: 15237060
Kuartil SJR: Q1
Citations: 5

## Authors
- Koga N.

## Abstract
A plant used in an Indonesian traditional herbal medicine as a diabetes treatment and known locally as "Jampu Salo" was collected on Sulawesi Island, Indonesia. It was identified as <i>Syzygium oblanceolatum</i> (C. B. Rob.) Merr. (Myrtaceae) and found for the first time in Sulawesi; it was previously reported only in the eastern Philippines and Borneo. A phytochemical study of <i>S. oblanceolatum</i> led to the isolation of three unprecedented meroterpenoids, syzygioblanes A-C (<b>1</b>-<b>3</b>, respectively). These compounds might be biosynthesized through [4+2] cycloaddition of various germacrane-based cyclic sesquiterpenoids with the flavone desmethoxymatteucinol to form a spiro skeleton. The unique and complex structures were elucidated by microcrystal electron diffraction analysis in addition to general analytical techniques such as high-resolution mass spectrometry, various nuclear magnetic resonance methods, and infrared spectroscopy. Synchrotron X-ray diffraction and calculations of electronic circular dichroism spectra helped to determine the absolute configurations. The newly isolated compounds exhibited collateral sensitivity to more strongly inhibit the growth of a multidrug resistant tumor cell line compared to a chemosensitive tumor cell line.

## Keywords
- Flavanone
- Indonesian
- Chemistry
- Sesquiterpene
- Stereochemistry
- Traditional medicine
- Hybrid
- Botany
- Organic chemistry
- Biology
- Philosophy
- Linguistics
- Flavonoid
- Medicine
- Antioxidant

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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