# Characteristics and prevalence of clinical remission of rheumatoid arthritis in a nationwide study from Indonesia
> Suryana B.P.P.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_85184193597
Jurnal / Konferensi: International Journal of Rheumatic Diseases
Tahun terbit: 2024
DOI: https://doi.org/10.1111/1756-185X.15050
ISSN: 17561841
Kuartil SJR: Q3
Citations: 4

## Authors
- Suryana B.P.P.

## Abstract
Abstract Aim To investigate the clinical characteristics, DMARD treatment pattern, remission rate, and factors associated with disease remission of rheumatoid arthritis (RA) patients in Indonesia. Method A multicenter survey was conducted in 2019–2020 involving 16 hospitals in Indonesia. Inclusion criteria were RA patients who fulfilled the 2010 ACR/EULAR classification criteria, were aged ≥18 years, and have been treated with 1 DMARD or more for at least 6 months, with exclusion criteria being the co‐existence of other autoimmune diseases or pain syndromes. Disease activities and remission rate were defined using DAS28‐ESR. Results A total of 870 patients were completed for analysis. Remission was achieved in 24.5% of patients, while low disease activity in 18.5%, moderate disease activity in 44.6%, and high disease activity in 12.4%. The distribution of conventional DMARDs from subjects was methotrexate 69.9%, leflunomide 15.9%, sulfasalazine 12.0%, chloroquine/hydroxychloroquine 8.9%, and cyclosporine 4.8%. Patients treated with biologic DMARDs were only 0.3%. The mean methotrexate dose was 11.2 ± 4.0 mg/week, and the mean methotrexate duration was 45.1 ± 36.6 months. The majority of patients received glucocorticoids (65.5%). 71.1% received DMARD monotherapy, while 28.9% had combined DMARDs. According to the multivariate analysis, delayed time to diagnosis and treatment (>6 months), DMARD monotherapy, and glucocorticoid use were negatively associated with disease remission. Conclusion The remission rate of Indonesian RA patients is 24.5%, and low disease activity is 18.5%. Methotrexate and leflunomide are the most frequent conventional DMARDs used. Delayed diagnosis, delayed treatment, and DMARD monotherapy contributed to the current low remission rate in Indonesia.

## Keywords
- Medicine
- Rheumatoid arthritis
- Internal medicine
- MEDLINE
- Family medicine
- Political science
- Law

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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