# Extract of Torbangun (Coleus amboinicus Lour) Leaves Inhibits the Expression of PEPCK and G6Pase in Streptozotocin-Induced Diabetic Rats
> Andrestian M.D.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_85183608368
Jurnal / Konferensi: Pharmacognosy Journal
Tahun terbit: 2023
DOI: https://doi.org/10.5530/pj.2023.15.203
ISSN: 09753575
Kuartil SJR: Q4
Citations: 0

## Authors
- Andrestian M.D.

## Abstract
Objective: This study aimed to analyze the anti-hyperglycemic activity of Torbangun leaf extract (TLE) in hyperglycemic rats by observing its effect on blood glucose levels and PEPCK and G6Pase gene expression. Method: This post-test-controlled group design study used a completely randomized design (CRD). Seven rats were separated as a normal group (N) and other rats were injected with streptozotocin (STZ). Hyperglycemia was characterized by fasting blood glucose (FBG) >126 mg/dl. Hyperglycemic rats were divided into three groups: H-IM (control drug metformin hydrochloride dose 62.5 mg/kg BW), H-IT (TLE dose 620mg/kg BB), and NG (negative control, hyperglycemic rats). Rats were given intervention for 14 days. Result: The results showed a significant difference between initial and final FBG of the HI-IM group (p = 0.002, α = 0.01) and the H-IT group (p = 0.005, α = 0.01) and effect on the key gene expression of gluconeogenesis in the liver. The H-IT group showed a decrease in PEPCK gene expression 0.80 times and decreased G6Pase gene expression by 0.65 times compared to NG group. Conclusion: The findings suggested the administration of TLE in STZ-induced hyperglycemic rats was able to reduce blood sugar levels and was involved in inhibiting the expression of PEPCK and G6Pase expression genes in the liver.

## Keywords
- Streptozotocin
- Gluconeogenesis
- Coleus
- Endocrinology
- Internal medicine
- Metformin
- Blood sugar
- Metformin Hydrochloride
- Medicine
- Gene expression
- Diabetes mellitus
- Phosphoenolpyruvate carboxykinase
- Pharmacology
- Chemistry
- Biology
- Gene
- Metabolism
- Biochemistry
- Botany

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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