# D-Dimer Analysis in COVID-19 Patients
> Mubarak A.R.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_85180268576
Jurnal / Konferensi: Indonesian Journal of Clinical Pathology and Medical Laboratory
Tahun terbit: 2021
DOI: https://doi.org/10.24293/ijcpml.v28i1.1812
ISSN: 24774685
Kuartil SJR: Q4
Citations: 7

## Authors
- Mubarak A.R.

## Abstract
The COVID-19 incidence is increasing around the world. Some countries are experiencing worsening conditions, evendeaths. One coagulation marker that noticeably increases in COVID-19 patients is D-dimer. This study aimed to analyzeD-dimer levels of COVID-19 patients. Retrospective study using medical records of 84 COVID-19 patients, conducted fromApril to August 2020 at UNHAS Hospital. Patients were grouped based on the severity of the disease as non-severe andsevere. D-dimer levels were measured using the Alere Triage® D-dimer with the fluorescent immunoassay method. Thestatistical test used was Mann-Whitney, D-dimer prognostic levels were calculated with ROC analysis to get the cut-off.Significant if the p < of 0.05. The sample consisted of 74 non-severe and ten severe COVID-19 patients, mostly in the 30-39age group. D-dimer levels in non-severe (0.31±0.38 μg/L) significantly differ from severe group (3.09±2.56 μg/L) (p<0.001).The Receiver Operating Characteristics (ROC) curve showed D-dimer sensitivity and specificity of 90.0% and 89.2%,respectively at the ≥ 0.80 μg/L cut-off, Negative Predictive Value (NPV) of 98.5%, and Positive Predictive Value (PPV) of52.9%. D-dimer levels increased in severe COVID-19 patients due to an increased inflammatory response resulting inexcessive thrombin. The ROC D-dimer curve indicated a cut-off rate of 0.80 μg/L, providing optimal sensitivity andspecificity. D-dimer has a significant difference in non-severe and severe COVID-19 patients and shows good value todetermine the severity of COVID-19 disease with a cut-off value ≥ 0.80 μg /L.

## Keywords
- Medicine
- D-dimer
- Receiver operating characteristic
- Gastroenterology
- Internal medicine
- Coronavirus disease 2019 (COVID-19)
- Mann–Whitney U test
- Disease
- Infectious disease (medical specialty)

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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