# Super-enhancer trapping by the nuclear pore via intrinsically disordered regions of proteins in squamous cell carcinoma cells
> Hazawa M.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_85177067446
Jurnal / Konferensi: Cell Chemical Biology
Tahun terbit: 2024
DOI: https://doi.org/10.1016/j.chembiol.2023.10.005
ISSN: 24519456
Kuartil SJR: Q1
Citations: 22

## Authors
- Hazawa M.

## Abstract
Master transcription factors such as TP63 establish super-enhancers (SEs) to drive core transcriptional networks in cancer cells, yet the spatiotemporal regulation of SEs within the nucleus remains unknown. The nuclear pore complex (NPC) may tether SEs to the nuclear pore where RNA export rates are maximal. Here, we report that NUP153, a component of the NPC, anchors SEs to the NPC and enhances TP63 expression by maximizing mRNA export. This anchoring is mediated through protein-protein interaction between the intrinsically disordered regions (IDRs) of NUP153 and the coactivator BRD4. Silencing of NUP153 excludes SEs from the nuclear periphery, decreases TP63 expression, impairs cellular growth, and induces epidermal differentiation of squamous cell carcinoma. Overall, this work reveals the critical roles of NUP153 IDRs in the regulation of SE localization, thus providing insights into a new layer of gene regulation at the epigenomic and spatial level.

## Keywords
- Nuclear pore
- Cell biology
- Gene silencing
- Nucleoporin
- Transcription factor
- Enhancer
- Biology
- Intrinsically disordered proteins
- Coactivator
- Nuclear localization sequence
- Nuclear transport
- Gene
- Cell nucleus
- Nucleus
- Genetics
- Biophysics

---
Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
Saat mengutip, gunakan DOI bila tersedia atau URL kanonis di atas.