# Exploratory study of ultraviolet B (UVB) radiation and age of onset of bipolar disorder
> Bauer M.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_85162906391
Jurnal / Konferensi: International Journal of Bipolar Disorders
Tahun terbit: 2023
DOI: https://doi.org/10.1186/s40345-023-00303-w
ISSN: 21947511
Kuartil SJR: Q1
Citations: 1

## Authors
- Bauer M.

## Abstract
BACKGROUND: Sunlight contains ultraviolet B (UVB) radiation that triggers the production of vitamin D by skin. Vitamin D has widespread effects on brain function in both developing and adult brains. However, many people live at latitudes (about > 40 N or S) that do not receive enough UVB in winter to produce vitamin D. This exploratory study investigated the association between the age of onset of bipolar I disorder and the threshold for UVB sufficient for vitamin D production in a large global sample. METHODS: Data for 6972 patients with bipolar I disorder were obtained at 75 collection sites in 41 countries in both hemispheres. The best model to assess the relation between the threshold for UVB sufficient for vitamin D production and age of onset included 1 or more months below the threshold, family history of mood disorders, and birth cohort. All coefficients estimated at P ≤ 0.001. RESULTS: The 6972 patients had an onset in 582 locations in 70 countries, with a mean age of onset of 25.6 years. Of the onset locations, 34.0% had at least 1 month below the threshold for UVB sufficient for vitamin D production. The age of onset at locations with 1 or more months of less than or equal to the threshold for UVB was 1.66 years younger. CONCLUSION: UVB and vitamin D may have an important influence on the development of bipolar disorder. Study limitations included a lack of data on patient vitamin D levels, lifestyles, or supplement use. More study of the impacts of UVB and vitamin D in bipolar disorder is needed to evaluate this supposition.

## Keywords
- Neurology
- Bipolar disorder
- Ultraviolet b
- Ultraviolet radiation
- Ultraviolet B radiation
- Psychology
- Psychopharmacology
- Medicine
- Psychiatry
- Dermatology
- Lithium (medication)
- Chemistry
- Radiochemistry

---
Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
Saat mengutip, gunakan DOI bila tersedia atau URL kanonis di atas.