# Neutrophil-lymphocyte ratio associated with Disease Activity Score-28 in patients with rheumatoid arthritis: a cross-sectional study
> Febriama A.N.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_85158995576
Jurnal / Konferensi: Gazzetta Medica Italiana Archivio Per Le Scienze Mediche
Tahun terbit: 2023
DOI: https://doi.org/10.23736/S0393-3660.22.04889-6
ISSN: 03933660
Kuartil SJR: Q4
Citations: 1

## Authors
- Febriama A.N.

## Abstract
BACKGROUND: Rheumatoid arthritis is the most prevalent inflammatory arthropathic illness and is characterized by ongoing synovial membrane inflammation. Neutrophil-lymphocyte ratio (NLR) is a measure of inflammation that is used to evaluate systemic inflammation. The purpose of this study was to investigate the association between NLR and the Disease Activity Score in 28 Joints (DAS-28) in patients with rheumatoid arthritis.METHODS: This was an analytic cross-sectional study of 49 participants. DAS-28 scores were calculated using C-reactive protein or erythrocyte sedimentation rate. The data were analyzed using Pearson’s correlation. The statistical results were considered significant if the P value was<0.05. If a significant relationship was found, the cut-off point of the NLR was determined using the receiver operating characteristic curve. Cochran-Mantel-Haenszel test performed to see Odds Ratio.RESULTS: The mean NLR of the sample was 4.57±3.6. DAS-28 score and NLR had a strong positive correlation (P<0.05), with an R value of 0.448, indicating a moderate correlation. The area under the curve was 0.88, and the NLR cut-off point was 2.96, with a sensitivity of 86.2% and specificity of 85%. In patients with NLR values ≥2.96, 86.2% had high disease activity, while in patients with NLR values<2.96, 85.0% had moderate disease activity. A patient with an NLR value of ≥2.96 had 35.17 times the risk of high disease activity (95% CI 7.70-178.01).CONCLUSIONS: This study revealed a relationship between NLR and RA disease activity level. Patients with an NLR value of 2.96 are at a higher risk of experiencing severe disease activity.

## Keywords
- Erythrocyte sedimentation rate
- Medicine
- Neutrophil to lymphocyte ratio
- Rheumatoid arthritis
- Internal medicine
- Receiver operating characteristic
- Gastroenterology
- Odds ratio
- Cross-sectional study
- Confidence interval
- Arthritis
- Lymphocyte
- Area under the curve
- Pathology

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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