# Prognostic Value of β-Catenin and L1CAM Expressions in Type I Endometrial Carcinoma
> Manule Y.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_85158125409
Jurnal / Konferensi: Asian Pacific Journal of Cancer Prevention
Tahun terbit: 2023
DOI: https://doi.org/10.31557/APJCP.2023.24.4.1413
ISSN: 15137368
Kuartil SJR: Q3
Citations: 5

## Authors
- Manule Y.

## Abstract
OBJECTIVE: The aim of this study is to evaluate the expression of β-catenin and L1CAM in the type I of Endometrial Carcinoma. MATERIAL AND METHODS: This study was an analytical study with a cross-sectional design using 49 samples of type I Endometrial Carcinoma. Immunohistochemical method was used to evaluate the expression of β-catenin and L1CAM related to two significant prognostic parameters i.e., lymphovascular space invasion (LVSI) and metastases event of type I Endometrial Carcinoma samples. RESULTS: From all samples collected, based on the presence of LVSI, there were 17 cases (34.7%) with LVSI and 32 (65.3%) no LVSI. Among them, there were 13 cases that included lymph node or omental samples in type I Endometrial Carcinoma, 5 (38.5%) cases of metastasis, and 8 (61.5%) cases that did not metastasize. The statistical results showed that there was a significant correlation between β-catenin and L1CAM expressions examined from tumor cells with lymphovascular space invasion and the presence of metastases in the type I Endometrial Carcinoma (p <0.05). CONCLUSION: This study suggest that the positive expression of β-catenin together with L1CAM can participate in the development of tumor cells in type I Endometrial Carcinoma, in its ability to involve lymphovascular space invasion, and metastases to other sites. Our results indicate that both of β-catenin and L1CAM are prominent biomarkers for the prognosis of type I Endometrial Carcinoma.

## Keywords
- Carcinoma
- Value (mathematics)
- Internal medicine
- Oncology
- Medicine
- Mathematics
- Statistics

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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