# A New Bis-indole Alkaloid, Spermaocymine A, and an Anthraquinone from Spermacoce ocymoides
> Rahim A.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_85156253890
Jurnal / Konferensi: Chemical and Pharmaceutical Bulletin
Tahun terbit: 2023
DOI: https://doi.org/10.1248/CPB.C23-00005
ISSN: 00092363
Kuartil SJR: Q3
Citations: 2

## Authors
- Rahim A.

## Abstract
A phytochemical study on Spermacoce ocymoides has led to the isolation of a novel bis-indole alkaloid, spermaocymine A (2), together with the known alkaloid 4-methyl-borreverine (1), as well as an anthraquinone, 8-hydroxy-2-(hydroxymethyl)-1-methoxyanthracene-9,10-dione (3). The structures of the isolated compounds were elucidated by analyzing spectroscopic and spectrometric data, including one-dimensional (1D)- and 2D-NMR and high resolution (HR)-MS. Newly isolated alkaloid 2 was a C-3,14-stereoisomer of 1, the first natural stereoisomer of related bis-indoles containing an indeno[1,2-b]indole skeleton with an epiminoethano bridge. When 1-3 were assayed against five tumor cell lines including multi-drug resistant cells, compound 1 exhibited potent antiproliferative activity with IC<sub>50</sub> values of 6.2-11.5 µM.

## Keywords
- Indole alkaloid
- Chemistry
- Alkaloid
- Stereochemistry
- Indole test
- Anthraquinone
- Hydroxymethyl
- Two-dimensional nuclear magnetic resonance spectroscopy
- Phytochemical
- Organic chemistry
- Biochemistry

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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