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Association between Sequential Organ Failure Assessment Score with Hemostasis Physiologic Disorder in Sepsis Patients
Wiradirnata R.A.
Gazzetta Medica Italiana Archivio Per Le Scienze Mediche
Q4Abstract
BACKGROUND: Every 3-4 seconds, someone in the world dies from sepsis. Early stratification of the prognosis in sepsis can be done through the Sequential Organ Failure Assessment (SOFA) Score. Sepsis patients were reported to have coagulation disorders including decreased platelets, increased prothrombin time (PT), increased activated partial thromboplastin time (APTT), increased fibrinogen, and increased D-dimer. Until now, however, it is not known whether the higher SOFA Score correlates with the severity of hemostatic function disorders in septic patients. The aim of this study was to determine the relationship between SOFA Scores and the severity of hemostatic function disorders in septic patients.METHODS: This study was a cross-sectional study with a total of 61 patients (35 men [57.4%]; median age was 54 (20-80) years. All patients were calculated with SOFA Scores and tested for blood hemostasis. Statistical analysis was performed to assess the correlation of SOFA Scores and blood hemostasis factors.RESULTS: The median SOFA Score in this study was 7 (with a range of 2-19). The median SOFA Score and APTT were significantly positively correlated with weak correlation coefficient. The median SOFA Score did not correlate significantly with PT values, fibrinogen levels, and D-dimer levels in this study. The SOFA Score cut-off of equals to or more than 7 was able to differentiate sepsis patients with and without prolongation of the APTT with sensitivity 59.4% and specificity 58.6%.CONCLUSIONS: In sepsis patients, higher SOFA Scores correlated with prolongation of APTT, but did not correlate with PT-INR values, fibrinogen levels, and D-dimer.