# Significance of medication discontinuation on bisphosphonate-related jaw osteonecrosis in a rat model
> Mustakim K.R.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_85143994094
Jurnal / Konferensi: Scientific Reports
Tahun terbit: 2022
DOI: https://doi.org/10.1038/s41598-022-25347-3
ISSN: 20452322
Kuartil SJR: Q1
Citations: 3

## Authors
- Mustakim K.R.

## Abstract
Bisphosphonate (BP) discontinuation has been advised as a measure to prevent the incidence of bisphosphonate-related osteonecrosis of the jaw (BRONJ), however, its efficacy remains controversial. This study aimed to analyze the efficacy of BP discontinuation in reducing BRONJ severity following tooth extraction in a rat model. Thirty-four male Sprague-Dawley rats were divided into two BRONJ model categories: oral administration (PO) of alendronate (1 mg/kg) for 3 and 8 weeks and intraperitoneal (IP) injection of pamidronate (3 mg/kg) and dexamethasone (1 mg/kg) for 20 days. The PO model was divided into five groups (a control group without BPs and four experimental groups with 1-week discontinuation). The IP model was divided into two groups consisting of group I (without discontinuation) and group II (1-week discontinuation). One molar from both sides of the mandible was extracted. After extraction, the PO models were sacrificed at 3 and 5 weeks, and the IP models were sacrificed either immediately or at 2, 4, 6, and 8 weeks. Micro-CT showed non-significant differences among PO groups but significant differences were observed between IP groups. Most bone remodeling parameters within group I of the IP model differed significantly (p-value < 0.05). Histologically, group I showed a significantly higher percentage of necrotic bone than group II (51.93 ± 12.75%, p < 0.05) and a higher number of detached osteoclasts in TRAP staining. With discontinuation of medication for at least 1 week in rats, the effects of BPs on alveolar bone are suppressed and bone turnover and osteoclast functions are restored.

## Keywords
- Discontinuation
- Medicine
- Bisphosphonate
- Osteonecrosis of the jaw
- Dexamethasone
- Incidence (geometry)
- Molar
- Internal medicine
- Dentistry
- Osteoporosis
- Physics
- Optics

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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